Discuss the differential diagnosis and investigation of a child below 3rd centile for height

Marking scheme for Calcium measurement Summer 2010

Marking scheme for question on Accuracy and BIAS Summer 2010

Marking scheme HPLC Question Summer 2010

Model Answer Acute Pancreatitis Summer 2010

Model answers Module 2 Q1 (Hypoglycaemia) Summer 2010

Model answers Module 4 Q1 (Iron) Summer 2010

Model answers Module 5 Q2 (Mineralocorticoid Hypertension) Summer 2010

Modules 1 & 4 SAQ Model Answers

Module 5&6 SAQ Model Answers

Module 2 SAQ Model Answers

Essay Questions Autumn 2009

HDL Methods Model Answer Summer 2010

                          

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Short Answer Questions. Answer all questions. Time allowed 1 hour.

There are 10 marks for each question

1)            Parathyroid hormone has a plasma half life of 3 minutes.  A patient undergoing a parathyroidectomy had an initial plasma value of 137 ng/L.  What was the level 11 minutes after isolation of the gland?  How long until the PTH level was undetectable? (Limit of detection = 5ng/L)

(5 marks each part)

2)              The following results were obtained on venous plasma glucose samples (mmol/L) during an oGTT

Fasting 2 hour Symptoms

Case 1 6.5 12.2 None

Case 2 6.6   7.8 None

Case 3 6.0   7.6 None

Case 4 6.9 15.0 Polyuria/Polydipsia

Case 5 6.1   7.7 None

Interpret the results in the light of the WHO criteria.

( 2 marks each)

3)            Define hypoglycaemia.  List 8 possible causes of hypoglycaemia in adults

(2 marks & 8 marks)

4)      Assuming the salt XCl₂ is completely dissociated in water and a 19g/L solution gave an osmolality of 600 mosmol/kg estimate the molecular weight of XCl₂

(10 marks)

5)      What volume of a stock glucose solution containing 9.01 g/L of glucose in saturated benzoic acid (5g/L) would be needed to make a litre of 8.33 mmol/L working standard?  What would be the concentration in g/L of benzoic acid in the final solution?

(6 marks & 4 marks)

6)     Write down the equation for Beer’s Law in terms of a) % transmission b) optical density.  State the units of any symbols used.

(6 marks & 4 marks)

7)      Calculate the hydrogen ion concentration in nmol/L of solutions of pH 6.9 and 7.6.

(5 marks each)

8)        Describe the current definitions for the metabolic syndrome

(10 marks)

9)  State the risk factors that are currently used to calculate cardiovascular disease risk.

(10 marks)

10)   Given the following patient results calculate the fractional excretion    of sodium:-

• • Serum:Urine
  • Sodium 146 mmol/L 50 mmol/L
  • Potassium    4.2 mmol/L
  • Chloride   94 mmol/L 57 mmol/L
  • Urea   34.4 mmol/L         100 mmol/L
  • Creatinine 450 umol/L   3.2 mmol/L
  • Osmolality 337 mmol/kg 325 mmol/kg

10 marks)