Essay Questions. Answer 2 questions only. Time allowed 1 hour 30 minutes.

1. Describe why there is variability in the way individuals metabolise different drugs. Give examples to illustrate your answer.
2. Outline the essential criteria for assessing a potential cancer screening programme. Illustrate your answer with specific examples.
3. Write an essay outlining the physiological importance of the catecholamines (noradrenaline, adrenaline and dopamine) and further describing the major routes of their metabolism and excretion.
4. Outline the essential features of a written operational requirement to be used in the procurement of an immunoanalyser system for a laboratory serving an 800 bed district general hospital.